NEUROCALM Clostridium Botulinum Toxin Type A

Neurocalm 100 Units (Clostridium botulinum Toxin Type A) is reconstituted only with preservative-free 0.9% sterile saline to 100 U/2.5 mL (4 U/0.1 mL). Using a 30-gauge needle, administer to five sites at glabellar lines, i.e. two sites at the respective corrugator muscle and one site at the procerus muscle at 0.1 mL each, 20 U in total.

A. Middle of corrugator supercilii muscle
B. Medial corrugator supercilia muscle
C. Procerus muscle

To reduce complications of drooping (ptosis) eyelids, avoid injection near the levator palpebrae superioris, for patients particularly with large corrugator muscles. When administering injection in the medial corrugator muscle and in the midpoint between each eyebrow, it must be done at a place at least 1 cm apart from the supraorbital ridge.

Be aware not to inject this drug into the blood vessel. To prevent effusion from the area below the orbital ridge, place a thumb or an index finger firmly on the area below the orbital ridge prior to injection.
During the injection, the needle should be pointes upward toward the center, and the injection dose must be accurate.
The corrugator muscle and the orbicularis oculi muscle move the middle of the forehead to create glabellar facial lines. The procerus and depressor supercilii muscles pull the forehead down. These muscles produce frowns or glabellar lines. Since the location, size, and use of muscles vary each other, the effective dose is determined by entire observation of the patient’s ability to actuate the injected superficial muscles.

Safety and efficacy of this drug for glabellar lines were assessed for 16 weeks after the single dose.
Safety and efficacy have not been clinically evaluated for frequent administration.